Neuromodulation and Neuroplasticity

Michael Fleischer studied medicine at the University Leipzig, where he graduated 2012. His doctoral thesis focused on the genetic characterization of glucose metabolism in high-grade glioma analysing PFKB2 isoforms in the group of Prof. K. Eschrich. Besides, he studied fatigue in patients with sarcoidosis in the group of Prof. E. Brähler under the supervision of Prof. A. Hinz. After graduation, Michael Fleischer started his residency in clinical neurology at the University Hospital Würzburg with Prof. J. Volkmann. Apart from clinics, he was involved into electrophysiological studies at the Institute for Clinical Neurobiology, where he established an electrophysiological patch-clamp setup and performed near infrared laser studies of human embryonic kidney cells and dorsal root ganglion neurons. In collaboration with Prof. H. Endres of School of Applied Science Würzburg-Schweinfurt, he developed an implantable stimulator for the exploration of deep brain stimulation in mice. He joined the NeuroScienceLab in 2017.

Michael Fleischer is interested in molecular and system biological processes that control neuronal plasticity and synapse formation in neurological diseases with a focus on stroke. Furthermore, he characterizes functional effects of chemotherapeutics in single neuron preparations.

Fleischer M, Kessler R, Klammer A, Warnke JP, Eschrich K. LOH on 10p14-p15 targets the PFKFB3 gene locus in human glioblastomas. Genes Chrom Cancer. 2011; 50:1010-20. 

Hinz A, Fleischer M, Brähler E, Wirtz H, Bosse-Henck A. Fatigue in patients with sarcoidosis, compared with the general population. Gen Hosp Psychiatry. 2011; 33:462-8.

Fleischer M, Hinz A, Brähler E, Wirtz H, Bosse-Henck A. Predictors of fatigue in patients with sarcoidosis. Respir Care. 2014; 59:1086-94. 

Fluri F, Fleischer M, Kleinschnitz C. Accidental thrombolysis in a stroke patient receiving apixaban. Cerebrovasc Dis Extra. 2015; 5:55-6.

Ning studied Clinical Medicine at Southwest Medical University from 2007 to 2012 when he received his bachelor degree. He received his master degree in Spinalsurgery at Southwest Medical University in 2016. Since June 2021 he started to study for his MD degree in the NeuroScienceLab under the supervision of Prof. Dirk Hermann.

Stroke is the most common cause of long-term disability and is associated with persistent functional neurological impairment in the vast majority of stroke patients. With the recent success of recanalization, there is a need to enhance follow-up therapy for neurological recovery after stroke injury. Ning’s research focuses on promoting exogenous neuronal plasticity through optogenetics stimulation of the hypothalamus to improve functional recovery after stroke.

Ning Luo, Xia He, Guangzhou Li, Yehui Liao, Qiang Tang, Rupei Ye, Dejun Zhong. Desmoid Tumor Presenting as a Typical Cervical Dumbbell Tumor:A Case Report and Literature Review. World Neurosurgery.2019,10,1878-8750(19):30033-6.

Yehui Liao, Qiang Tang, Chao Tang, Ning Luo, Fei Ma, Dejun Zhong, Qing Wang. Application of pain management in enhancing patient recovery after percutaneous kyphoplasty surgery. West China Medical Journal, 2018, 33(9):1173-1176.

Chao Tang, Yehui Liao, Qiang Tang, Fei Ma, Ning Luo, Sheng Yang, Hongchun He, Dejun Zhong. Clinical efficacy of intraoperative hemostatic gauze covering teared dura meter in the treatment of cerebrospinal fluid leakage during lumbar spine surgery. Chinese Journal of Spine and Spinal Cord, 2018, 28(9): 819-825.

Fei Ma, Yehui Liao, Qiang Tang, Chao Tang, Ning Luo, Sheng Yang, Hongchun He, Dejun Zhong. Influence of HBV infection on wound healing of incision after single-level open posterior instrumented lumbar fusion and correlated factors analysis. Chinese Journal of Spine and Spinal Cord, 2018, 28(7): 634-640.