Isolated thalamic strokes are rare but lead to long-lasting impairment in memory and higher-order cognitive functions. Previous studies on symptoms after thalamic strokes are mostly single-case studies or recruit small patient cohorts. In a prospective study we recruit patients with isolated thalamic strokes prospectively at different clinics and examine these patients in the acute, postacute and chronic stroke phase using neurological and neuropsychological assessment and structural magnetic resonance imaging (MRI) (Figure 1) to analyse secondary neurodegeneration processes and their consequences after stroke.

Figure 1. Research methods. Magnetic resonance imaging of the brain (left), neuropsychological assessment (middle), neurological examination (right).


Scharf AC, Gronewold J, Todica O, Moenninghoff C, Doeppner TR, de Haan B, Bassetti CLA, Hermann DM. Evolution of Neuropsychological Deficits in First-Ever Isolated Ischemic Thalamic Stroke and Their Association With Stroke Topography: A Case-Control Study. Stroke. 2022;53(6):1904-14.

Hermann DM, Bassetti CL. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology. 2016; 87(13):1407-16.

Hermann DM, Siccoli M, Brugger P, Wachter K, Mathis J, Achermann P, Bassetti CL. Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke. Stroke. 2008; 39(1):62-8. 

Janine Gronewold, PhD



Anne-Carina Scharf, MD