Publications
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CD73 activity of mesenchymal stromal cell-derived extracellular vesicle preparations is detergent-resistant and does not correlate with immunomodulatory capabilities. Bauer, F.N., Tertel, T., Stambouli, O., Wang, C., Dittrich, R., Staubach, S., Börger, V., Hermann, D.M., Brandau, S., and Giebel, B. (2023). Cytotherapy 25, 138-147.
Age-Associated Resilience Against Ischemic Injury in Mice Exposed to Transient Middle Cerebral Artery Occlusion. Beker, M.C., Aydinli, F.I., Caglayan, A.B., Beker, M., Baygul, O., Caglayan, A., Popa-Wagner, A., Doeppner, T.R., Hermann, D.M., and Kilic, E. (2023). Mol. Neurobiol. 60, 4359-4372.
Neurotoxicity of ischemic astrocytes involves STAT3-mediated metabolic switching and depends on glycogen usage. Borbor, M., Yin, D., Brockmeier, U., Wang, C., Doeckel, M., Pillath-Eilers, M., Kaltwasser, B., Hermann, D.M., and Dzyubenko, E. (2023). Glia 71, 1553-1569.
Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis. Burlacu, C.-C., Ciobanu, D., Badulescu, A.-V., Chelaru, V.-F., Mitre, A.-O., Capitanescu, B., Hermann, D.M., and Popa-Wagner, A. (2023). Int. J. Mol. Sci. 24, 251.
The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte–Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity. Caglayan, A.B., Beker, M.C., Sertel Evren, E., Caglayan, B., Kilic, Ü., Ates, N., Caglayan, A., Dasdelen, M.F., Doeppner, T.R., Saarma, M., Hermann, D.M., and Kilic, E. (2023). Transl Stroke Res 14, 263-277.
Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective. Coliță, C.-I., Olaru, D.-G., Coliță, D., Hermann, D.M., Coliță, E., Glavan, D., and Popa-Wagner, A. (2023). Int. J. Mol. Sci. 24, 5744.
Impact of NKG2D Signaling on Natural Killer and T-Cell Function in Cerebral Ischemia. David, C., Ruck, T., Rolfes, L., Mencl, S., Kraft, P., Schuhmann, M.K., Schroeter, C.B., Jansen, R., Langhauser, F., Mausberg, A.K., Fender, A.C., Meuth, S.G., and Kleinschnitz, C. (2023). J. Am. Heart Assoc. 12, e029529.
Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system. Dzyubenko, E., and Hermann, D.M. (2023). Semin. Immunopathol. 45, 377-387.
Editorial: The role of inflammation in neurodegenerative diseases. Dzyubenko, E., Sardari, M., and Hermann, D.M. (2023). Front. Cell. Neurosci. 17.
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke. Dzyubenko, E., Willig, K.I., Yin, D., Sardari, M., Tokmak, E., Labus, P., Schmermund, B., and Hermann, D.M. (2023). J. Biomed. Sci. 30, 76.
Editorial: Crosstalk between peripheral and local immune response in the pathophysiology of stroke and neurodegeneration diseases. Fang, Y., Shao, A., Huang, L., Tang, J., Zhang, X., and Hermann, D.M. (2023). Front. Cell. Neurosci. 17.
Association of regional white matter hyperintensities with hypertension and cognition in the population-based 1000BRAINS study. Gronewold, J., Jokisch, M., Schramm, S., Himpfen, H., Ginster, T., Tenhagen, I., Doeppner, T.R., Jockwitz, C., Miller, T., Lehmann, N., Moebus, S., Jöckel, K.-H., Erbel, R., Caspers, S., Hermann, D.M., and Group, t.H.N.R.S.I. (2023). Eur. J. Neurol. 30, 1174-1190.
Hot topics in cellular neuropathology III: using CRISPR/Cas9 technology for deciphering central nervous system disease targets. Hermann, D.M. (2023). Front. Cell. Neurosci. 17.
Treatment concept successfully translated into human patients. Hermann, D.M. (2023). Exploration of Neuroscience 2, 48-51.
Editorial: Hot topics in cellular neuropathology, volume II: promoting neuronal plasticity in the injured central nervous system. Hermann, D.M., Bacigaluppi, M., and Peruzzotti-Jametti, L. (2023). Front. Cell. Neurosci. 17.
Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer’s disease. Kronimus, Y., Albus, A., Hasenberg, M., Walkenfort, B., Seifert, M., Budeus, B., Gronewold, J., Hermann, D.M., Ross, J.A., Lochnit, G., Galuska, S.P., Marcus, K., Sitek, B., Klotsche, J., Mengel, D., Neumann, S., and Dodel, R. (2023). Alzheimer’s & dementia : the journal of the Alzheimer’s Association.
Analysis of Free Circulating Messenger Ribonucleic Acids in Serum Samples from Late-Onset Spinal Muscular Atrophy Patients Using nCounter NanoString Technology. Leo, M., Schmitt, L.-I., Mairinger, F., Roos, A., Hansmann, C., Hezel, S., Skuljec, J., Pul, R., Schara-Schmidt, U., Kleinschnitz, C., and Hagenacker, T. (2023). Cells 12, 2374.
BAG3 Overexpression Attenuates Ischemic Stroke Injury by Activating Autophagy and Inhibiting Apoptosis. Liu, X., Ye, Q., Huang, Z., Li, X., Zhang, L., Liu, X., Wu, Y.-C., Brockmeier, U., Hermann, D.M., Wang, Y.-C., and Ren, L. (2023). Stroke 54, 2114-2125.
Editorial: Modulating microglia to enhance neuroplasticity for restoring brain function after stroke. Liu, Z., Hermann, D.M., Dzyubenko, E., Cao, G., and Cao, X. (2023). Front. Cell. Neurosci. 17.
Developing a novel tool to assess the ability to self-administer medication – A systematic evaluation of patients’ video recordings in the ABLYMED study. Luegering, A., Langner, R., Wilm, S., Doeppner, T.R., Hermann, D.M., Frohnhofen, H., and Gronewold, J. (2023). Frontiers in Medicine 10.
Schlaf und Demenz. Mayer, G., Stenmanns, C., Doeppner, T.R., Hermann, D.M., and Gronewold, J. (2023). Z. Gerontol. Geriatr.
Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor modulating factors. Nording, H.M., Baron, L., Sauter, M., Lübken, A., Rawish, E., Szepanowski, R.D., von Esebeck, J., Sun, Y., Emami, H., Meusel, M., Saraei, R., Schanze, N., Gorantla, S.P., von Bubnoff, N., Geisler, T., von Hundelshausen, P., Stellos, K., Marquardt, J., Sadik, C., Koehl, J., Duerschmied, D., Kleinschnitz, C., and Langer, H.F. (2023). Blood Advances.
Brainstem Infarction in Immunodeficiency Identified as Adenosine Deaminase 2 Deficiency: Case Report. Oster, C., Stolte, B., Asan, L., Pul, R., Klebe, S., Köhrmann, M., Breuckmann, K., Rischpler, C., Deuschl, C., Dolff, S., Kleinschnitz, C., and Hagenacker, T. (2023). J. Clin. Immunol. 43, 1597-1602.
Immune Response to Seasonal Influenza Vaccination in Multiple Sclerosis Patients Receiving Cladribine. Rolfes, L., Pfeuffer, S., Skuljec, J., He, X., Su, C., Oezalp, S.-H., Pawlitzki, M., Ruck, T., Korsen, M., Kleinschnitz, K., Aslan, D., Hagenacker, T., Kleinschnitz, C., Meuth, S.G., and Pul, R. (2023). Cells 12, 1243.
Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review. Ruscu, M., Cercel, A., Kilic, E., Catalin, B., Gresita, A., Hermann, D.M., Albu, C.V., and Popa-Wagner, A. (2023). Int. J. Mol. Sci. 24, 10802.
Genetic plasma biomarkers associated with ischemic stroke. Ruscu, M.A., Burdusel, D., Cercel, A.-m., Aldea, M., Hermann, D.M., Cadenas, I.F., Doeppner, T.R., Surugiu, R., and Popa-Wagner, A. (2023). Exploration of Neuroscience 2, 27-47.
Iatrogenic Air Embolisms During Endovascular Interventions: Impact of Origin and Number of Air Bubbles on Cerebral Infarctions. Schaefer, T.C., Greive, S., Mencl, S., Heiland, S., Kramer, M., Möhlenbruch, M.A., Kleinschnitz, C., Bendszus, M., and Vollherbst, D.F. (2023). Clin. Neuroradiol.
Depression and anxiety in acute ischemic stroke involving the anterior but not paramedian or inferolateral thalamus. Scharf, A.-C., Gronewold, J., Eilers, A., Todica, O., Moenninghoff, C., Doeppner, T.R., de Haan, B., Bassetti, C.L., and Hermann, D.M. (2023). Front. Psychol. 14.
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy. Schmitt, L.-I., David, C., Steffen, R., Hezel, S., Roos, A., Schara-Schmidt, U., Kleinschnitz, C., Leo, M., and Hagenacker, T. (2023). Acta Neuropathol. 145, 611-635.
Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs. Spangenberg, P., Hagemann, N., Squire, A., Förster, N., Krauß, S.D., Qi, Y., Mohamud Yusuf, A., Wang, J., Grüneboom, A., Kowitz, L., Korste, S., Totzeck, M., Cibir, Z., Tuz, A.A., Singh, V., Siemes, D., Struensee, L., Engel, D.R., Ludewig, P., Martins Nascentes Melo, L., Helfrich, I., Chen, J., Gunzer, M., Hermann, D.M., and Mosig, A. (2023). Cell Reports Methods 3, 100436.
Response Letter to Vink et al. ‘Neurological Study Does Not Provide Any Evidence that Long COVID is Psychosomatic’. Stettner, M., Fleischer, M., Skoda, E.-M., Teufel, M., and Kleinschnitz, C. (2023). Neurology and Therapy 12, 333-336.
Surugiu, R., Burdusel, D., Ruscu, M.-A., Cercel, A., Hermann, D.M., Cadenas, I.F., and Popa-Wagner, A. (2023). Clinical Ageing. In Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science, J.R. Harris, and V.I. Korolchuk, eds. (Springer International Publishing), pp. 437-458. 10.1007/978-3-031-26576-1_16.
Time for a standardized diagnostic response test in patients with chronic inflammatory demyelinating polyradiculoneuropathy? Szepanowski, F., Schoser, B., Mausberg, A.K., Kleinschnitz, C., Hartung, H.P., and Stettner, M. (2023). Brain Behav, e3256.
High-dose biotin neither fosters remyelination nor stimulates malonyl coenzyme A synthesis in the regenerating nerve. Szepanowski, F., Steubing, R.D., Güngör, C., Zipfel, J., Mausberg, A.K., Kleinschnitz, C., and Stettner, M. (2023). Neural regeneration research 18, 1623-1624.
Corneal confocal microscopy reveals small nerve fibre loss correlating with motor function in adult spinal muscular atrophy. Thimm, A., Brakemeier, S., Dag, M., Munoz Rosales, J., Stolte, B., Kleinschnitz, C., Stettner, M., and Hagenacker, T. (2023). Eur. J. Neurol. 30, 2821-2827.
Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation. Xin, W., Pan, Y., Wei, W., Tatenhorst, L., Graf, I., Popa-Wagner, A., Gerner, S.T., Huber, S., Kilic, E., Hermann, D.M., Bähr, M., Huttner, H.B., and Doeppner, T.R. (2023). Theranostics 13, 4197-4216.
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages. Yin, D., Wang, C., Qi, Y., Wang, Y.-C., Hagemann, N., Mohamud Yusuf, A., Dzyubenko, E., Kaltwasser, B., Tertel, T., Giebel, B., Gunzer, M., Popa-Wagner, A., Doeppner, T.R., and Hermann, D.M. (2023). J. Neuroinflamm 20, 210.
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice. Ates, N., Caglayan, A., Balcikanli, Z., Sertel, E., Beker, M.C., Dilsiz, P., Caglayan, A.B., Celik, S., Dasdelen, M.F., Caglayan, B., Yigitbasi, T., Ozbek, H., Doeppner, T.R., Hermann, D.M., and Kilic, E. (2022). Exp. Neurol. 351, 113996.
Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration. Balçıkanlı, Z., Culha, I., Dilsiz, P., Aydin, M.S., Ates, N., Beker, M.C., Baltaci, S.B., Koc, H.I., Yigitbasi, A., Gündogar, M., Doeppner, T.R., Hermann, D.M., and Kilic, E. (2022). Front. Cell. Neurosci. 16.
Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury. Beckmann, L., Obst, S., Labusek, N., Abberger, H., Köster, C., Klein-Hitpass, L., Schumann, S., Kleinschnitz, C., Hermann, D.M., Felderhoff-Müser, U., Bendix, I., Hansen, W., and Herz, J. (2022). Stroke 53, 381-390.
Phosphodiesterase 10A Is a Critical Target for Neuroprotection in a Mouse Model of Ischemic Stroke. Beker, M.C., Caglayan, A.B., Altunay, S., Ozbay, E., Ates, N., Kelestemur, T., Caglayan, B., Kilic, U., Doeppner, T.R., Hermann, D.M., and Kilic, E. (2022). Mol. Neurobiol. 59, 574-589.
Phosphodiesterase 10A deactivation induces long-term neurological recovery, Peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice. Beker, M.C., Pence, M.E., Yagmur, S., Caglayan, B., Caglayan, A., Kilic, U., Yelkenci, H.E., Altintas, M.O., Caglayan, A.B., Doeppner, T.R., Hermann, D.M., and Kilic, E. (2022). Exp. Neurol. 358, 114221.
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia. Beuker, C., Schafflick, D., Strecker, J.-K., Heming, M., Li, X., Wolbert, J., Schmidt-Pogoda, A., Thomas, C., Kuhlmann, T., Aranda-Pardos, I., A-Gonzalez, N., Kumar, P.A., Werner, Y., Kilic, E., Hermann, D.M., Wiendl, H., Stumm, R., Meyer zu Hörste, G., and Minnerup, J. (2022). Nat Commun 13, 945.
Severe and long-lasting alteration of albumin redox state by plasmapheresis. Boss, K., Stettner, M., Szepanowski, F., Mausberg, A.K., Paar, M., Pul, R., Kleinschnitz, C., Oettl, K., and Kribben, A. (2022). Sci. Rep. 12, 12165.
Treatment of Adult Spinal Muscular Atrophy: Overview and Recent Developments. Brakemeier, S., Stolte, B., Kleinschnitz, C., and Hagenacker, T. (2022). Curr. Pharm. Des. 28, 1-7.
Editorial: Blood-Brain Barrier Dysregulation and Recovery Following Brain Ischemia: Cellular Constituents, Molecular Mechanisms, and Therapeutic Strategies Enabling Successful Brain Remodeling. Chen, H., Cao, Z., Gu, Y., and Hermann, D.M. (2022). Front. Cell. Neurosci. 16.
Therapeutic Use and Chronic Abuse of CNS Stimulants and Anabolic Drugs. Coliță, D., Coliță, C.-I., Hermann, D.M., Coliță, E., Doeppner, T.R., Udristoiu, I., and Popa-Wagner, A. (2022). Curr. Issues Mol. Biol. 44, 4902-4920.
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism. Doeppner, T.R., Coman, C., Burdusel, D., Ancuta, D.L., Brockmeier, U., Pirici, D.N., Yaoyun, K., Hermann, D.M., and Popa-Wagner, A. (2022). Aging (Albany N. Y.) 14, 4195-4210.
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats. Dumbrava, D.-A., Surugiu, R., Börger, V., Ruscu, M., Tertel, T., Giebel, B., Hermann, D.M., and Popa-Wagner, A. (2022). GeroScience 44, 293-310.
Editorial: Perspectives of Astrocytes in Neurodevelopmental and Neurodegenerative Diseases: From Mechanistic Studies to Therapeutic Applications. Dzyubenko, E., Hermann, D.M., and Wang, J. (2022). Front. Cell. Neurosci. 16.
Tenascin-C restricts reactive astrogliosis in the ischemic brain. Dzyubenko, E., Manrique-Castano, D., Pillath-Eilers, M., Vasileiadou, P., Reinhard, J., Faissner, A., and Hermann, D.M. (2022). Matrix Biol. 110, 1-15.
Essen transition model for neuromuscular diseases. Fleischer, M., Coskun, B., Stolte, B., Della-Marina, A., Kölbel, H., Lax, H., Nonnemacher, M., Kleinschnitz, C., Schara-Schmidt, U., and Hagenacker, T. (2022). Neurological Research and Practice 4, 41.
Anti-EBNA1 IgG titre is not associated with fatigue in multiple sclerosis patients. Fleischer, M., Schuh, H., Bickmann, N.M., Hagenacker, T., Krüger, K., Skripuletz, T., Fiedler, M., Kleinschnitz, C., Pul, R., and Skuljec, J. (2022). Neurol. Neurochir. Pol. 56, 236-245.
Post-COVID-19 Syndrome is Rarely Associated with Damage of the Nervous System: Findings from a Prospective Observational Cohort Study in 171 Patients. Fleischer, M., Szepanowski, F., Tovar, M., Herchert, K., Dinse, H., Schweda, A., Mausberg, A.K., Holle-Lee, D., Köhrmann, M., Stögbauer, J., Jokisch, D., Jokisch, M., Deuschl, C., Skoda, E.-M., Teufel, M., Stettner, M., and Kleinschnitz, C. (2022). Neurology and Therapy 11, 1637-1657.
Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats. Gresita, A., Mihai, R., Hermann, D.M., Amandei, F.S., Capitanescu, B., and Popa-Wagner, A. (2022). GeroScience 44, 211-228.
Association between life events and later depression in the population-based Heinz Nixdorf Recall study—The role of sex and optimism. Gronewold, J., Duman, E.-E., Engel, M., Engels, M., Siegrist, J., Erbel, R., Jöckel, K.H., and Hermann, D.M. (2022). PLoS One 17, e0271716.
Periventricular rather than deep white matter hyperintensities mediate effects of hypertension on cognitive performance in the population-based 1000BRAINS study. Gronewold, J., Jokisch, M., Schramm, S., Himpfen, H., Ginster, T., Tenhagen, I., Doeppner, T.R., Jockwitz, C., Miller, T., Lehmann, N., Moebus, S., Jöckel, K.-H., Erbel, R., Caspers, S., and Hermann, D.M. (2022). J. Hypertens. 40, 2413-2422.
Imaging innate immunity*. Grüneboom, A., Aust, O., Cibir, Z., Weber, F., Hermann, D.M., and Gunzer, M. (2022). Immunol. Rev. 306, 293-303.
CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells. Guse, K., Hagemann, N., Thiele, L., Remlinger, J., Salmen, A., Hoepner, R., Keller, I., Meyer, P., Grandgirard, D., Leib, S.L., Vassella, E., Locatelli, G., Hermann, D.M., and Chan, A. (2022). Neurology – Neuroimmunology Neuroinflammation 9, e1168.
Cutting edges in neuroscience to exceed borders. Hermann, D.M. (2022a). Exploration of Neuroscience 1, 1-3.
Hot Topics in Cellular Neuropathology II: Promoting Neuronal Plasticity in the Injured Central Nervous System. Hermann, D.M. (2022). Front. Cell. Neurosci. 16.
Editorial: Hot Topics in Cellular Neuropathology. Hermann, D.M., Popa-Wagner, A., Peruzzotti-Jametti, L., and Gunzer, M. (2022). Front. Cell. Neurosci. 16.
Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke. Hermann, D.M., Xin, W., Bähr, M., Giebel, B., and Doeppner, T.R. (2022). Theranostics 12, 5776-5802.
Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy. Leo, M., Schmitt, L.-I., Fleischer, M., Steffen, R., Osswald, C., Kleinschnitz, C., and Hagenacker, T. (2022). Cells 11, 558.
Correction to “A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke”. Liu, Y., Wang, X., Li, X., Qiao, S., Huang, G., Hermann, D.M., Doeppner, T.R., Zeng, M., Liu, W., Xu, G., Ren, L., Zhang, Y., Liu, W., Casals, E., Li, W., and Wang, Y.-C. (2022). ACS Applied Materials & Interfaces 14, 44015-44015.
Developing a novel tool to assess the ability to self-administer medication in non-demented in-hospital patients: ABLYMED study protocol. Maiworm, A., Langner, R., Wilm, S., Hermann, D.M., Frohnhofen, H., and Gronewold, J. (2022). BMC Geriatr. 22, 466.
Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives. Meyer, S.F.D., Langhauser, F., Haupeltshofer, S., Kleinschnitz, C., and Casas, A.I. (2022). Stroke 53, 1487-1499.
Roles of Polymorphonuclear Neutrophils in Ischemic Brain Injury and Post-Ischemic Brain Remodeling. Mohamud Yusuf, A., Hagemann, N., Ludewig, P., Gunzer, M., and Hermann, D.M. (2022). Front. Immunol. 12.
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Mohamud Yusuf, A., Hagemann, N., Zhang, X., Zafar, M., Hussner, T., Bromkamp, C., Martiny, C., Tertel, T., Börger, V., Schumacher, F., Solari, F.A., Hasenberg, M., Kleinschnitz, C., Doeppner, T.R., Kleuser, B., Sickmann, A., Gunzer, M., Giebel, B., Kolesnick, R., Gulbins, E., and Hermann, D.M. (2022). Basic Res. Cardiol. 117, 43.
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Rohlfing, A.-K., Kolb, K., Sigle, M., Ziegler, M., Bild, A., Münzer, P., Sudmann, J., Dicenta, V., Harm, T., Manke, M.-C., Geue, S., Kremser, M., Chatterjee, M., Liang, C., von Eysmondt, H., Dandekar, T., Heinzmann, D., Günter, M., von Ungern-Sternberg, S., Büttcher, M., Castor, T., Mencl, S., Langhauser, F., Sies, K., Ashour, D., Beker, M.C., Lämmerhofer, M., Autenrieth, S.E., Schäffer, T.E., Laufer, S., Szklanna, P., Maguire, P., Heikenwalder, M., Müller, K.A.L., Hermann, D.M., Kilic, E., Stumm, R., Ramos, G., Kleinschnitz, C., Borst, O., Langer, H.F., Rath, D., and Gawaz, M. (2022). Nat Commun 13, 1823.
Natural Killer Cells Are Present in Rag1−/− Mice and Promote Tissue Damage During the Acute Phase of Ischemic Stroke. Rolfes, L., Ruck, T., David, C., Mencl, S., Bock, S., Schmidt, M., Strecker, J.-K., Pfeuffer, S., Mecklenbeck, A.-S., Gross, C., Gliem, M., Minnerup, J., Schuhmann, M.K., Kleinschnitz, C., and Meuth, S.G. (2022). Transl Stroke Res 13, 197-211.
ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke. Schanbacher, C., Bieber, M., Reinders, Y., Cherpokova, D., Teichert, C., Nieswandt, B., Sickmann, A., Kleinschnitz, C., Langhauser, F., and Lorenz, K. (2022). Int. J. Mol. Sci. 23, 706.
Evolution of Neuropsychological Deficits in First-Ever Isolated Ischemic Thalamic Stroke and Their Association With Stroke Topography: A Case-Control Study. Scharf, A.-C., Gronewold, J., Todica, O., Moenninghoff, C., Doeppner, T.R., Haan, B.d., Bassetti, C.L.A., and Hermann, D.M. (2022). Stroke 53, 1904-1914.
Post-ischemic protein restriction induces sustained neuroprotection, neurological recovery, brain remodeling, and gut microbiota rebalancing. Silva de Carvalho, T., Singh, V., Mohamud Yusuf, A., Wang, J., Schultz Moreira, A.R., Sanchez-Mendoza, E.H., Sardari, M., Nascentes Melo, L.M., Doeppner, T.R., Kehrmann, J., Scholtysik, R., Hitpass, L., Gunzer, M., and Hermann, D.M. (2022). Brain. Behav. Immun. 100, 134-144.
Platelet depletion does not alter long-term functional outcome after cerebral ischaemia in mice. Steubing, R.D., Szepanowski, F., David, C., Mohamud Yusuf, A., Mencl, S., Mausberg, A.-K., Langer, H.F., Sauter, M., Deuschl, C., Forsting, M., Fender, A.C., Hermann, D.M., Casas, A.I., Langhauser, F., and Kleinschnitz, C. (2022). Brain, Behavior, & Immunity – Health 24, 100493.
N-Methyl-D-Aspartate Receptors Antagonist Prevents Secondary Ischemic Brain Injury Associated With Lipopolysaccharide-Induced Sepsis-Like State Presumably via Immunomodulatory Actions. Taheri, G., Sardari, M., Hermann, D.M., and Sepehri, H. (2022). Front. Cell. Neurosci. 16.
Assessment of Health-Related Quality of Life in Adult Spinal Muscular Atrophy Under Nusinersen Treatment—A Pilot Study. Thimm, A., Brakemeier, S., Kizina, K., Munoz Rosales, J., Stolte, B., Totzeck, A., Deuschl, C., Kleinschnitz, C., and Hagenacker, T. (2022a). Front. Neurol. 12.
Corneal confocal microscopy to detect early immune-mediated small nerve fibre loss in AL amyloidosis. Thimm, A., Carpinteiro, A., Oubari, S., Papathanasiou, M., Kessler, L., Rischpler, C., Malik, R.A., Reinhardt, H.C., Rassaf, T., Herrmann, K., Kleinschnitz, C., Stettner, M., and Hagenacker, T. (2022). Ann Clin Transl Neurol.
Prevalence and predictors of neurological manifestations in systemic AL amyloidosis. Thimm, A., Carpinteiro, A., Oubari, S., Papathanasiou, M., Luedike, P., Kessler, L., Rischpler, C., Blau, T., Reinhardt, H.C., Rassaf, T., Schmidt, H., Kleinschnitz, C., and Hagenacker, T. (2022). J. Neurol. Sci. 440, 120341.
Total Plasma Exchange in Neuromuscular Junction Disorders – A Single-Center, Retrospective Analysis of the Efficacy, Safety and Potential Diagnostic Properties in Doubtful Diagnosis. Totzeck, A., Jahn, M., Stolte, B., Thimm, A., Kleinschnitz, C., and Hagenacker, T. (2022). J Clin Med 11, 4383.
Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery. Tuz, A.A., Hasenberg, A., Hermann, D.M., Gunzer, M., and Singh, V. (2022). Front. Immunol. 13.
Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice. Wang, C., Börger, V., Yusuf, A.M., Tertel, T., Stambouli, O., Murke, F., Freund, N., Kleinschnitz, C., Herz, J., Gunzer, M., Popa-Wagner, A., Doeppner, T.R., Giebel, B., and Hermann, D.M. (2022). Stroke 53, e14-e18.
Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain. Wang, C., Giebel, B., and Hermann, D.M. (2022). Exploration of Neuroscience 1, 61-74.
Editorial: Brain injury and repair following cerebrovascular diseases: From bench to bedside. Wang, G., Li, Q., Shao, A., He, Y., Huang, L., and Hermann, D.M. (2022). Front. Cell. Neurosci. 16.
Hypocaloric Diet Initiated Post-Ischemia Provides Long-Term Neuroprotection and Promotes Peri-Infarct Brain Remodeling by Regulating Metabolic and Survival-Promoting Proteins. de Carvalho, T.S., Sanchez-Mendoza, E.H., Schultz Moreira, A.R., Nascentes Melo, L.M., Wang, C., Sardari, M., Hagemann, N., Doeppner, T.R., Kleinschnitz, C., and Hermann, D.M. (2021). Mol. Neurobiol. 58, 1491-1503.
The Need for New Biomarkers to Assist with Stroke Prevention and Prediction of Post-Stroke Therapy Based on Plasma-Derived Extracellular Vesicles. Driga, M.P., Catalin, B., Olaru, D.G., Slowik, A., Plesnila, N., Hermann, D.M., and Popa-Wagner, A. (2021). Biomedicines 9, 1226.
Inhibitory control in neuronal networks relies on the extracellular matrix integrity. Dzyubenko, E., Fleischer, M., Manrique-Castano, D., Borbor, M., Kleinschnitz, C., Faissner, A., and Hermann, D.M. (2021). Cell. Mol. Life Sci. 78, 5647–5663
Analysing Intercellular Communication in Astrocytic Networks Using “Astral”. Dzyubenko, E., Prazuch, W., Pillath-Eilers, M., Polanska, J., and Hermann, D.M. (2021). Front. Cell. Neurosci. 15.
Corneal confocal microscopy differentiates inflammatory from diabetic neuropathy. Fleischer, M., Lee, I., Erdlenbruch, F., Hinrichs, L., Petropoulos, I.N., Malik, R.A., Hartung, H.-P., Kieseier, B.C., Kleinschnitz, C., and Stettner, M. (2021). J. Neuroinflamm 18, 89.
Sleep in Elderly Adults and in Subjects with Dementia. In Sleep Neurology: A Comprehensive Guide to Basic and Clinical Aspects, L.M. DelRosso, and R. Ferri, eds. Frohnhofen, H., and Hermann, D.M. (2021). (Springer International Publishing), pp. 289-300.
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. Gimona, M., Brizzi, M.F., Choo, A.B.H., Dominici, M., Davidson, S.M., Grillari, J., Hermann, D.M., Hill, A.F., de Kleijn, D., Lai, R.C., Lai, C.P., Lim, R., Monguió-Tortajada, M., Muraca, M., Ochiya, T., Ortiz, L.A., Toh, W.S., Yi, Y.W., Witwer, K.W., Giebel, B., and Lim, S.K. (2021). Cytotherapy 23, 373-380.
Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims. Glavan, D., Gheorman, V., Gresita, A., Hermann, D.M., Udristoiu, I., and Popa-Wagner, A. (2021). Sci. Rep. 11, 18853.
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Gregorius, J., Wang, C., Stambouli, O., Hussner, T., Qi, Y., Tertel, T., Börger, V., Yusuf, A.M., Hagemann, N., Yin, D., Dittrich, R., Mouloud, Y., Mairinger, F.D., Magraoui, Fouzi E., Popa-Wagner, A., Kleinschnitz, C., Doeppner, T.R., Gunzer, M., Meyer, H.E., Giebel, B., and Hermann, D.M. (2021). Basic Res. Cardiol. 116, 40.
Effects of Life Events and Social Isolation on Stroke and Coronary Heart Disease. Gronewold, J., Engels, M., Velde, S.v.d., Cudjoe, T.K.M., Duman, E.-E., Jokisch, M., Kleinschnitz, C., Lauterbach, K., Erbel, R., Jöckel, K.-H., and Hermann, D.M. (2021). Stroke 52, 735-747.
Social isolation and risk of fatal cardiovascular events. Gronewold, J., and Hermann, D.M. (2021). The Lancet Public Health 6, e197-e198.
Association of Blood Pressure, Its Treatment, and Treatment Efficacy With Volume of White Matter Hyperintensities in the Population-Based 1000BRAINS Study. Gronewold, J., Jokisch, M., Schramm, S., Jockwitz, C., Miller, T., Lehmann, N., Moebus, S., Jöckel, K.-H., Erbel, R., Caspers, S., and Hermann, D.M. (2021). Hypertension 78, 1490-1501.
Population impact of different hypertension management guidelines based on the prospective population-based Heinz Nixdorf Recall study. Gronewold, J., Kropp, R., Lehmann, N., Stang, A., Mahabadi, A.A., Weimar, C., Dichgans, M., Moebus, S., Kröger, K., Hoffmann, B., Jöckel, K.-H., Erbel, R., and Hermann, D.M. (2021). BMJ Open 11, e039597.
Developing an Alternative Version of the Epworth Sleepiness Scale to Assess Daytime Sleepiness in Adults with Physical or Mental Disabilities.
Gronewold, J., Lenuck, M.C.I., Gülderen, I., Scharf, A.C., Penzel, T., Johns, M.W., Frohnhofen, H., and Hermann, D.M. (2021). Gerontology 67, 49-59.
Lost in the Translation Trap: Quest for a Research Reporting Culture That More Carefully Weighs Clinical Applicability in Experimental Disease Models. Hermann, D.M. (2021). Front. Cell. Neurosci. 15.
Circulating MicroRNAs: Posttranscriptional Regulators and Disease Markers Holding Promise in Stroke Prediction. Hermann, D.M., Doeppner, T.R., and Giebel, B. (2021). Stroke 52, 954-956.
New Light on the Horizon: Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic Stroke. Hermann, D.M., Doeppner, T.R., and Giebel, B. (2021). Stroke 52, 3348-3350.
Modulating Microglial Cells for Promoting Brain Recovery and Repair. Hermann, D.M., and Gunzer, M. (2021). Front. Cell. Neurosci. 14.
Implications of immune responses for ischemic brain injury and stroke recovery. Hermann, D.M., Liesz, A., and Dzyubenko, E. (2021). Brain. Behav. Immun. 96, 292-294.
Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model. Janssen, L., Ai, X., Zheng, X., Wei, W., Caglayan, A.B., Kilic, E., Wang, Y.-c., Hermann, D.M., Venkataramani, V., Bähr, M., and Doeppner, T.R. (2021). Front. Cell. Neurosci. 15.
Targeting epigenetic modifiers to reprogramme macrophages in non-resolving inflammation-driven atherosclerosis. Jin, F., Li, J., Guo, J., Doeppner, T.R., Hermann, D.M., Yao, G., and Dai, Y. (2021). European Heart Journal Open 1.
Cognitive Impairment in Adult Patients with 5q-Associated Spinal Muscular Atrophy. Kizina, K., Akkaya, Y., Jokisch, D., Stolte, B., Totzeck, A., Munoz-Rosales, J., Thimm, A., Bolz, S., Brakemeier, S., Pul, R., Aslan, D., Hackert, J., Kleinschnitz, C., and Hagenacker, T. (2021). Brain Sciences 11, 1184.
Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood–brain barrier damage, and inflammation. Leinweber, J., Mizurini, D.M., Francischetti, I.M.B., Fleischer, M., Hermann, D.M., Kleinschnitz, C., and Langhauser, F. (2021). Brain. Behav. Immun. 93, 288-298.
Cisplatin-induced activation and functional modulation of satellite glial cells lead to cytokine-mediated modulation of sensory neuron excitability. Leo, M., Schmitt, L.-I., Kutritz, A., Kleinschnitz, C., and Hagenacker, T. (2021). Exp. Neurol. 341, 113695.
Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel Kir4.1 Expression in Cultured Spinal Cord Astrocytes by Platinum-Based Chemotherapeutics. Leo, M., Schmitt, L.-I., Steffen, R., Kutritz, A., Kleinschnitz, C., and Hagenacker, T. (2021). Int. J. Mol. Sci. 22, 6300.
A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke. Liu, Y., Wang, X., Li, X., Qiao, S., Huang, G., Hermann, D.M., Doeppner, T.R., Zeng, M., Liu, W., Xu, G., Ren, L., Zhang, Y., Liu, W., Casals, E., Li, W., and Wang, Y.-C. (2021). ACS Appl. Mater. Inter. 13, 46213-46224.
Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain. Manrique-Castano, D., Dzyubenko, E., Borbor, M., Vasileiadou, P., Kleinschnitz, C., Roll, L., Faissner, A., and Hermann, D.M. (2021). Brain. Behav. Immun. 91, 639-648.
Light Sheet Microscopy Using FITC-Albumin Followed by Immunohistochemistry of the Same Rehydrated Brains Reveals Ischemic Brain Injury and Early Microvascular Remodeling. Mohamud Yusuf, A., Hagemann, N., Schulten, S., Rausch, O., Wagner, K., Hussner, T., Qi, Y., Totzeck, M., Kleinschnitz, C., Squire, A., Gunzer, M., and Hermann, D.M. (2021). Front. Cell. Neurosci. 14.
Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia–ischemia. Mülling, K., Fischer, A.J., Siakaeva, E., Richter, M., Bordbari, S., Spyra, I., Köster, C., Hermann, D.M., Gunzer, M., Felderhoff-Müser, U., Bendix, I., Jablonska, J., and Herz, J. (2021). Brain. Behav. Immun. 92, 232-242.
p5 Peptide-Loaded Human Adipose-Derived Mesenchymal Stem Cells Promote Neurological Recovery After Focal Cerebral Ischemia in a Rat Model. Paudyal, A., Ghinea, F.S., Driga, M.P., Fang, W.-H., Alessandri, G., Combes, L., Degens, H., Slevin, M., Hermann, D.M., and Popa-Wagner, A. (2021). Transl Stroke Res 12, 125-135.
Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration. Sardari, M., Skuljec, J., Yin, D., Zec, K., de Carvalho, T.S., Albers, D., Wang, C., Pul, R., Popa-Wagner, A., Doeppner, T.R., Kleinschnitz, C., Dzyubenko, E., and Hermann, D.M. (2021). Brain. Behav. Immun. 91, 627-638.
Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs. Singh, V., Beer, A., Kraus, A., Mang, F., Zhang, X., Xue, J., Hagemann, N., Hermann, D.M., and Gunzer, M. (2021). Brain. Behav. Immun. 94, 458-462.
Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters. Stolte, B., Nonnemacher, M., Kizina, K., Bolz, S., Totzeck, A., Thimm, A., Wagner, B., Deuschl, C., Kleinschnitz, C., and Hagenacker, T. (2021). J. Neurol. 268, 4667-4679.
Secondary Immunodeficiency and Risk of Infection Following Immune Therapies in Neurology. Szepanowski, F., Warnke, C., Meyer zu Hörste, G., Mausberg, A.K., Hartung, H.-P., Kleinschnitz, C., and Stettner, M. (2021). CNS Drugs 35, 1173-1188.
LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis. Szepanowski, F., Winkelhausen, M., Steubing, R.D., Mausberg, A.K., Kleinschnitz, C., and Stettner, M. (2021). J. Neuroinflamm 18, 293.
Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia. Xin, W.Q., Wei, W., Pan, Y.L., Cui, B.L., Yang, X.Y., Bähr, M., and Doeppner, T.R. (2021). World J. Stem Cells 13, 1030-1048.
Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice. Zhang, L., Graf, I., Kuang, Y., Zheng, X., Haupt, M., Majid, A., Kilic, E., Hermann, D.M., Psychogios, M.-N., Weber, M.S., Ochs, J., Bähr, M., and Doeppner, T.R. (2021). Arterioscler. Thromb. Vasc. Biol. 41, 1127-1145.
Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Zhang, L., Wei, W., Ai, X., Kilic, E., Hermann, D.M., Venkataramani, V., Bähr, M., and Doeppner, T.R. (2021). Cell Death Dis. 12, 1068.
The role of small extracellular vesicles in cerebral and myocardial ischemia—Molecular signals, treatment targets, and future clinical translation. Zheng, X., Hermann, D.M., Bähr, M., and Doeppner, T.R. (2021). Stem Cells 39, 403-413.
Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice. Zheng, X., Zhang, L., Kuang, Y., Venkataramani, V., Jin, F., Hein, K., Zafeiriou, M.P., Lenz, C., Moebius, W., Kilic, E., Hermann, D.M., Weber, M.S., Urlaub, H., Zimmermann, W.H., Bähr, M., and Doeppner, T.R. (2021). Transl Stroke Res 12, 185-203.
Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats. Balseanu, A.T., Grigore, M., Pinosanu, L.-R., Slevin, M., Hermann, D.M., Glavan, D., and Popa-Wagner, A. (2020). Front. Neurosci. 14.
Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins. Beker, M., Caglayan, A.B., Beker, M.C., Altunay, S., Karacay, R., Dalay, A., Altintas, M.O., Kose, G.T., Hermann, D.M., and Kilic, E. (2020). Exp. Neurol. 331, 113364.
Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial. Chabriat, H., Bassetti, C.L., Marx, U., Audoli-Inthavong, M.-L., Sors, A., Lambert, E., Wattez, M., Hermann, D.M., Althaus, K., Amaro, S., Bae, H.-J., Bak, Z., Barbarini, L., Bassi, P., Bazan, R., Bereczki, D., Berkowicz, T., Berrouschot, J., Blacquiere, D., Brola, W., Butcher, K., Cardona, P., Cha, J.-K., Cloud, G., Cohen, D., Cordonnier, C., Csanyi, A., Czlonkowska, A., Davis, S., Dawson, J., De Klippel, N., Denier, C., Desfontaines, P., Diener, H.-C., Dioszeghy, P., Dippel, D.W., Dorado, L., Folyovich, A., Freitas, G.R., Friedrich, M.A., Fryze, W., Gagliardi, R.J., Gottschal, M., Grimley, R., Grond, M., GrÖSchel, K., Hosseini, H., Hwang, Y., Kallmuenzer, B., Khan, U., Kim, J.S., Kleinig, T., Koves, A., Lago Martin, A., Lasek-Bal, A., Lembo, G., Lemmens, R., Lindert, R., Porcello Marrone, L.C., Martinez Zabaleta, M., Mas, J.-L., Masjuan Vallejo, J., Mazighi, M., Minelli, C., Mistri, A., Molina, C., Moniche Alvarez, F., Cabral Moro, C.H., Mulleners, W., Nabavi, D., Neau, J.-P., O’Brien, B., Ovary, C., Panczel, G., Park, M.S., Phan, T., Ragab, S., Rejdak, K., Rodriguez De Freitas, G., Roffe, C., Roquer Gonzalez, J., Rover, L., Sampaio Silva, G., Schellinger, P., Segura Martin, T., Shaw, L., Sibon, I., Skoda, O., Smadja, D., Sobolewski, P., Soda, H., Sprigg, N., Swiat, M., Szapary, L., Szegedi, N., Toni, D., Valikovics, A., Vanhooren, G., Vecsei, L., Wein, T., Wong, A., and Ximenez Carrillo, A. (2020). Lancet Neurol. 19, 226-233.
Randomized Efficacy and Safety Trial with Oral S 44819 after Recent ischemic cerebral Event (RESTORE BRAIN study): a placebo controlled phase II study. Chabriat, H., Bassetti, C.L., Marx, U., Picarel-Blanchot, F., Sors, A., Gruget, C., Saba, B., Wattez, M., Audoli, M.-L., and Hermann, D.M. (2020). Trials 21, 136.
Cell motility and migration as determinants of stem cell efficacy. Danielyan, L., Schwab, M., Siegel, G., Brawek, B., Garaschuk, O., Asavapanumas, N., Buadze, M., Lourhmati, A., Wendel, H.-P., Avci-Adali, M., Krueger, M.A., Calaminus, C., Naumann, U., Winter, S., Schaeffeler, E., Spogis, A., Beer-Hammer, S., Neher, J.J., Spohn, G., Kretschmer, A., Krämer-Albers, E.-M., Barth, K., Lee, H.J., Kim, S.U., Frey, W.H., Claussen, C.D., Hermann, D.M., Doeppner, T.R., Seifried, E., Gleiter, C.H., Northoff, H., and Schäfer, R. (2020). EBioMedicine 60, 102989.
Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice. de Carvalho, T.S., Sanchez-Mendoza, E.H., Nascentes Melo, L.M., Schultz Moreira, A.R., Sardari, M., Dzyubenko, E., Kleinschnitz, C., and Hermann, D.M. (2020). Transl Stroke Res 11, 135-146.
Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats. Filfan, M., Olaru, A., Udristoiu, I., Margaritescu, C., Petcu, E., Hermann, D.M., and Popa-Wagner, A. (2020). GeroScience 42, 937-949.
FoxP3 deficiency causes no inflammation or neurodegeneration in the murine brain. Gingele, S., Pul, R., Sardari, M., Borbor, M., Henkel, F., Moellenkamp, T.M., Gudi, V., Happle, C., Grychtol, R., Habener, A., Hansen, G., Hermann, D.M., Stangel, M., Kleinschnitz, C., and Skuljec, J. (2020). J. Neuroimmunol. 342, 577216.
Association of social relationships with incident cardiovascular events and all-cause mortality. Gronewold, J., Kropp, R., Lehmann, N., Schmidt, B., Weyers, S., Siegrist, J., Dragano, N., Jöckel, K.-H., Erbel, R., and Hermann, D.M. (2020). Heart 106, 1317-1323.
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia. Hagemann, N., Mohamud Yusuf, A., Martiny, C., Zhang, X., Kleinschnitz, C., Gunzer, M., Kolesnick, R., Gulbins, E., and Hermann, D.M. (2020). Basic Res. Cardiol. 115, 64.
Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice. Haupt, M., Zechmeister, B., Bosche, B., Lieschke, S., Zheng, X., Zhang, L., Venkataramani, V., Jin, F., Hein, K., Weber, M.S., Hermann, D.M., Bähr, M., and Doeppner, T.R. (2020). Neuropharmacology 181, 108357.
Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation. Haupt, M., Zheng, X., Kuang, Y., Lieschke, S., Janssen, L., Bosche, B., Jin, F., Hein, K., Kilic, E., Venkataramani, V., Hermann, D.M., Bähr, M., and Doeppner, T.R. (2020). Stem Cells Transl. Med. 10, 357-373.
Hot Topics in Cellular Neuropathology. Hermann, D.M. (2020). Front. Cell. Neurosci. 14.
Refining endpoints for stroke recovery trials. Hermann, D.M., Bassetti, C.L., Marx, U., Audoli-Inthavong, M.-L., and Chabriat, H. (2020). Lancet Neurol. 19, 381-382.
Thrombomodulin, a Master Switch Controlling Poststroke Microvascular Remodeling and Angiogenesis. Hermann, D.M., and Kleinschnitz, C. (2020). Arterioscler. Thromb. Vasc. Biol. 40, 2818-2820.
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury. Kaminski, N., Köster, C., Mouloud, Y., Börger, V., Felderhoff-Müser, U., Bendix, I., Giebel, B., and Herz, J. (2020). Front. Cell. Neurosci. 14.
Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25. Kuang, Y., Zheng, X., Zhang, L., Ai, X., Venkataramani, V., Kilic, E., Hermann, D.M., Majid, A., Bähr, M., and Doeppner, T.R. (2020). J Extracell Vesicles 10, e12024.
Platinum-Based Drugs Cause Mitochondrial Dysfunction in Cultured Dorsal Root Ganglion Neurons. Leo, M., Schmitt, L.-I., Küsterarent, P., Kutritz, A., Rassaf, T., Kleinschnitz, C., Hendgen-Cotta, U.B., and Hagenacker, T. (2020). Int. J. Mol. Sci. 21, 8636.
CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age. Lieschke, S., Zechmeister, B., Haupt, M., Zheng, X., Jin, F., Hein, K., Weber, M.S., Hermann, D.M., Bähr, M., Kilic, E., and Doeppner, T.R. (2020). Cells 9, 66.
NK cell markers predict the efficacy of IV immunoglobulins in CIDP. Mausberg, A.K., Heininger, M.K., Meyer Zu Horste, G., Cordes, S., Fleischer, M., Szepanowski, F., Kleinschnitz, C., Hartung, H.-P., Kieseier, B.C., and Stettner, M. (2020). Neurol Neuroimmunol Neuroinflamm 7, e884.
A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer’s disease family. Mengel, D., Liu, L., Yamamoto, R., Zülow, S., Deuschl, C., Hermann, D.M., Zerr, I., Selkoe, D.J., and Dodel, R. (2020). Neurobiol. Aging 85, 154.e155-154.e157.
Postacute administration of the GABAA α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats. Pace, M., Falappa, M., Machado, P., Facchin, L., Hermann, D.M., and Bassetti, C.L. (2020). Clin Transl Neurosci 4, 2514183X20948306.
Correction to: Genetic conversion of proliferative astroglia into neurons after cerebral ischemia: a new therapeutic tool for the aged brain? Popa-Wagner, A., Hermann, D.M., and Gresita, A. (2020). GeroScience 42, 373-373.
Ageing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic. Popa-Wagner, A., Petcu, E.B., Capitanescu, B., Hermann, D.M., Radu, E., and Gresita, A. (2020). Mech. Ageing Dev. 190, 111312.
A clinically relevant model of stroke using aged rats. Popa-Wagner, A., Popescu-Driga, M., Pinosanu, L.-R., Grigore, M., Ghinea, F.S., Capitanescu, B., and Hermann, D.M. (2020). Vascular Cell, 6%V 12.
Long-term exposure to ambient source-specific particulate matter and its components and incidence of cardiovascular events – The Heinz Nixdorf Recall study. Rodins, V., Lucht, S., Ohlwein, S., Hennig, F., Soppa, V., Erbel, R., Jöckel, K.-H., Weimar, C., Hermann, D.M., Schramm, S., Moebus, S., Slomiany, U., and Hoffmann, B. (2020). Environ. Int. 142, 105854.
Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression Model. Sanchez-Mendoza, E.H., Camblor-Perujo, S., Martins Nascentes-Melo, L., Dzyubenko, E., Fleischer, M., Silva de Carvalho, T., Schmitt, L.-I., Leo, M., Hagenacker, T., Herring, A., Keyvani, K., Bera, S., Kononenko, N., Kleinschnitz, C., and Hermann, D.M. (2020). Mol. Neurobiol. 57, 3171-3182.
Dose-Dependent Microglial and Astrocytic Responses Associated With Post-ischemic Neuroprotection After Lipopolysaccharide-Induced Sepsis-Like State in Mice. Sardari, M., Dzyubenko, E., Schmermund, B., Yin, D., Qi, Y., Kleinschnitz, C., and Hermann, D.M. (2020). Front. Cell. Neurosci. 14.
Modulating endothelial adhesion and migration impacts stem cell therapies efficacy. Schäfer, R., Schwab, M., Siegel, G., von Ameln-Mayerhofer, A., Buadze, M., Lourhmati, A., Wendel, H.-P., Kluba, T., Krueger, M.A., Calaminus, C., Scheer, E., Dominici, M., Grisendi, G., Doeppner, T.R., Schlechter, J., Finzel, A.K., Gross, D., Klaffschenkel, R., Gehring, F.K., Spohn, G., Kretschmer, A., Bieback, K., Krämer-Albers, E.-M., Barth, K., Eckert, A., Elser, S., Schmehl, J., Claussen, C.D., Seifried, E., Hermann, D.M., Northoff, H., and Danielyan, L. (2020). EBioMedicine 60, 102987.
Clinical and functional patient characteristics predict medical needs in older patients at risk of functional decline. Scharf, A.-C., Gronewold, J., Dahlmann, C., Schlitzer, J., Kribben, A., Gerken, G., Frohnhofen, H., Dodel, R., and Hermann, D.M. (2020). BMC Geriatr. 20, 75.
Activation and functional modulation of satellite glial cells by oxaliplatin lead to hyperexcitability of sensory neurons in vitro. Schmitt, L.-I., Leo, M., Kutritz, A., Kleinschnitz, C., and Hagenacker, T. (2020). Mol Cell Neurosci 105, 103499.
Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model. Sokolova, V., Nzou, G., van der Meer, S.B., Ruks, T., Heggen, M., Loza, K., Hagemann, N., Murke, F., Giebel, B., Hermann, D.M., Atala, A.J., and Epple, M. (2020). Acta Biomater. 111, 349-362.
Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis. Thiele née Schrewe, L., Guse, K., Tietz, S., Remlinger, J., Demir, S., Pedreiturria, X., Hoepner, R., Salmen, A., Pistor, M., Turner, T., Engelhardt, B., Hermann, D.M., Lühder, F., Wiese, S., and Chan, A. (2020). J. Neuroinflamm 17, 9.
Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils. Wang, C., Börger, V., Sardari, M., Murke, F., Skuljec, J., Pul, R., Hagemann, N., Dzyubenko, E., Dittrich, R., Gregorius, J., Hasenberg, M., Kleinschnitz, C., Popa-Wagner, A., Doeppner, T.R., Gunzer, M., Giebel, B., and Hermann, D.M. (2020). Stroke 51, 1825-1834.
Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB) Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice. Zhang, L., Graf, I., Kuang, Y., Zheng, X., Haupt, M., Majid, A., Kilic, E., Hermann, D.M., Psychogios, M.-N., Weber, M.S., Ochs, J., Bähr, M., and Doeppner, T.R. (2020). Arterioscler. Thromb. Vasc. Biol. 0, ATVBAHA.120.315031
Validity and Reliability of Neurological Scores in Mice Exposed to Middle Cerebral Artery Occlusion. Bieber, M., Gronewold, J., Scharf, A.-C., Schuhmann, M.K., Langhauser, F., Hopp, S., Mencl, S., Geuss, E., Leinweber, J., Guthmann, J., Doeppner, T.R., Kleinschnitz, C., Stoll, G., Kraft, P., and Hermann, D.M. (2019). Stroke 50, 2875-2882.
Acute and Post-acute Neuromodulation Induces Stroke Recovery by Promoting Survival Signaling, Neurogenesis, and Pyramidal Tract Plasticity. Caglayan, A.B., Beker, M.C., Caglayan, B., Yalcin, E., Caglayan, A., Yulug, B., Hanoglu, L., Kutlu, S., Doeppner, T.R., Hermann, D.M., and Kilic, E. (2019). Front. Cell. Neurosci. 13.
Moderate Protein Restriction Protects Against Focal Cerebral Ischemia in Mice by Mechanisms Involving Anti-inflammatory and Anti-oxidant Responses. de Carvalho, T.S., Sanchez-Mendoza, E.H., Nascentes, L.M., Schultz Moreira, A.R., Sardari, M., Dzyubenko, E., Kleinschnitz, C., and Hermann, D.M. (2019). Mol. Neurobiol. 56, 8477-8488.
Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke. Giebel, B., and Hermann, D.M. (2019). Ann. Transl. Med. 7, 188.
Very Low Efficiency of Direct Reprogramming of Astrocytes Into Neurons in the Brains of Young and Aged Mice After Cerebral Ischemia. Gresita, A., Glavan, D., Udristoiu, I., Catalin, B., Hermann, D.M., and Popa-Wagner, A. (2019). Front. Aging Neurosci. 11.
Sleep-Disordered Breathing in Hospitalized Geriatric Patients with Mild Dementia and Its Association with Cognition, Emotion and Mobility. Gronewold, J., Haensel, R., Kleinschnitz, C., Frohnhofen, H., and Hermann, D.M. (2019). Int. J. Environ. Res. Public Health 16, 863.
Cardiovascular Risk and Atherosclerosis Progression in Hypertensive Persons Treated to Blood Pressure Targets. Gronewold, J., Kropp, R., Lehmann, N., Stang, A., Mahabadi, A.A., Kälsch, H., Weimar, C., Dichgans, M., Budde, T., Moebus, S., Jöckel, K.-H., Erbel, R., and Hermann, D.M. (2019). Hypertension 74, 1436-1447.
Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies. Hermann, D.M., Doeppner, T.R., and Popa-Wagner, A. (2019). Neural Plast. 2019, 9785476.
Contribution of polymorphonuclear neutrophils in the blood periphery to ischemic brain injury. Hermann, D.M., and Gunzer, M. (2019). Neurol.: Neuroimmunol. NeuroInflammation 6, e570.
Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke. Hermann, D.M., and Gunzer, M. (2019). Stroke 50, e40-e41.
Modeling Vascular Risk Factors for the Development of Ischemic Stroke Therapies. Hermann, D.M., and Kleinschnitz, C. (2019). Stroke 50, 1310-1317.
Animal models of ischemic stroke and their impact on drug discovery. Hermann, D.M., Popa-Wagner, A., Kleinschnitz, C., and Doeppner, T.R. (2019). Expert Opin Drug Discov 14, 315-326.
Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFα and angiogenic VEGF. Jin, F., Zheng, X., Yang, Y., Yao, G., Ye, L., Doeppner, T.R., Hermann, D.M., Wang, H., and Dai, Y. (2019). Aging 11, 328-349.
Forschergruppe (FOR 2879) ImmunoStroke: Von der Immunzelle zur Schlaganfallregeneration. Kleinschnitz, C., and Langhauser, F. (2019). Neuroforum 25, 267-269.
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes. Manrique-Castano, D., Sardari, M., Silva de Carvalho, T., Doeppner, T.R., Popa-Wagner, A., Kleinschnitz, C., Chan, A., and Hermann, D.M. (2019). Front. Cell. Neurosci. 13.
Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response. Merz, S.F., Korste, S., Bornemann, L., Michel, L., Stock, P., Squire, A., Soun, C., Engel, D.R., Detzer, J., Lörchner, H., Hermann, D.M., Kamler, M., Klode, J., Hendgen-Cotta, U.B., Rassaf, T., Gunzer, M., and Totzeck, M. (2019). Nat Commun 10, 2768.
The Acid Sphingomyelinase/ Ceramide System as Target for Ischemic Stroke Therapies. Mohamud Yusuf, A., Hagemann, N., and Hermann, D.M. (2019). Neurosignals 27, 32-43.
Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment. Scharf, A.-C., Gronewold, J., Dahlmann, C., Schlitzer, J., Kribben, A., Gerken, G., Rassaf, T., Kleinschnitz, C., Dodel, R., Frohnhofen, H., and Hermann, D.M. (2019). BMC Geriatr. 19, 221.
Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury. Surugiu, R., Catalin, B., Dumbrava, D., Gresita, A., Olaru, D.G., Hermann, D.M., and Popa-Wagner, A. (2019). Neural Plast. 2019, 1071036.
Recent Advances in Mono- and Combined Stem Cell Therapies of Stroke in Animal Models and Humans. Surugiu, R., Olaru, A., Hermann, D.M., Glavan, D., Catalin, B., and Popa-Wagner, A. (2019). Int. J. Mol. Sci. 20, 6029.
Glyphosate-based herbicide: a risk factor for demyelinating conditions of the peripheral nervous system? Szepanowski, F., Kleinschnitz, C., and Stettner, M. (2019). Neural Regen Res 14, 2079-2080.