Bei Benutzung wird die Seite neugeladen
Barrierefreie Anpassungen
Wählen Sie Ihre Einstellungen
Seheinschränkungen Unterstützung für Menschen, die schlecht sehen
Texte vorlesen Hilfestellung für Nutzer, die Probleme beim Lesen von Onlinetexten haben
Kognitive Einschränkungen Hilfestellung beim Lesen und beim Erkennen wichtiger Elemente
Neigung zu Krampfanfällen Animationen werden deaktiviert und gefährliche Farbkombinationen reduziert
Konzentrationsschwäche Ablenkungen werden reduziert und ein klarer Fokus gesetzt
Screenreader Die Website wird so verändert, das sie mit Screenreadern kompatibel ist
Tastatursteuerung Die Webseite kann mit der Tastatur genutzt werden
Alle Einstellungen zurücksetzen Ihre Einstellungen zur Barrierefreiheit werden auf den Standard zurückgesetzt
Individuelle Anpassungen
Schriftgröße
Zeilenabstand
Inhaltsgröße
Wortabstand
Zeichenabstand
Hintergrundfarbe
Textfarbe
Linkfarbe
Titelfarbe

Experimental studies of the recent past have shown that neurological recovery can be stimulated by neuronal plasticity-promoting therapies post-stroke in rodents. Using video-based behavioral tests, histochemical and molecular biological techniques, this group examines, how neuronal plasticity after stroke can be promoted by growth factors (e.g., erythropoietin), cell-based therapeutics (e.g., neural stem and precursor cells, stem cell-derived exosomes) and pharmacological compounds (i.e., drugs). An important focus of our works is the characterization of axonal connectivity by means of anterograde and retrograde tract tracing methods (Figure 1). Research results of the group already led to the translation of a pharmacological compound, the GABAA-α5 antagonist S44819, into a large worldwide clinical phase II multicenter study, RESTORE Brain, which is currently performed in Europe, North and South America, Asia and Australia in stroke patients.

Our research projects at a glance:

  • Effects of growth factors, cell-based therapeutics and pharmacological compounds on neurological recovery, neuronal plasticity and brain remodeling after focal cerebral ischemia
  • Analysis of axonal connectivity by anterograde and retrograde tract tracers
  • Analysis of dendritic arborizations and synaptic densities using Golgi-Cox stainings
  • Effects of age, vascular risk factors (e.g., dyslipidemia) and dietary influences (lipid-rich nutrition, malnutrition) on neurological recovery and neuronal plasticity
  • Effects of disturbed blood-brain barrier integrity (following deactivation of ATP-binding cassette transporters) on neurological recovery and neuronal plasticity

Publications

Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, Kilic E, Kilic U, Salani G, Brambilla E, West MJ, Comi G, Martino G, Hermann DM. Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain. 2009; 132:2239-51.

Hermann DM, Chopp M. Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 2012; 11:369-80.

Reitmeir R, Kilic E, Kilic U, Bacigaluppi M, ElAli A, Salani G, Pluchino S, Gassmann M, Hermann DM. Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain. 2011; 134:84-99.

Reitmeir R, Kilic E, Reinboth BS, Guo Z, ElAli A, Zechariah A, Kilic U, Hermann DM. Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain. Acta Neuropathol. 2012; 123:273-84. 

Wang YC, Sanchez-Mendoza EH, Doeppner TR, Hermann DM. Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity. J Cereb Blood Flow Metab. 2016; May 11.

Dongpei Yin, MSc

MD student

Email
Biosketch

Chen Wang, MD, PhD

Postdoc

Email
Biosketch

Xiaolong Liu, MSc

MD student

Email
Biosketch
Mitarbeiter Platzhalter Bild

Prof. Aurel Popa, PhD

Email

Britta Kaltwasser

Biotechnical Assistant

Email
Biosketch